Applications in diseases processes

 

I. Elucidating the decoding mechanisms of ubiquitin signals and their significance in neurodegenerative/neurodevelopment diseases (as part of the Sagol School of Neuroscience) 

Projects in the lab include: Molecular mechanisms that regulate membrane protein trafficking and Parkinson’s disease Mechanisms for regulation of sodium / potassium channels and dopamine transporter.

The molecular basis of the involvement of the ubiquitin E3-ligases in Autism and Kufmann syndromes

The involvement of ubiquitin-receptors in amyloid formation.

 

We developed E. coli models for these diseases in which the bacteria became addicted to functional expression of ubiquitylation cascades involve in the disease. A full description of the system is described in our Nature Methods paper

 

II. Pathogenic bacteria such as enterohaemorrhagic E. coli (EHEC) employ multiple strategies to evade, subvert and hijack the host cellular pathways for their own benefits. As the Ub system functions as a pivotal regulator, many of the effectors delivered by these pathogens target the Ub-system.